The problem with many of the best fat burners is that they contain many stimulants that rev up your metabolism, but may leave you feeling a little too jacked up. That is not the case with the products that contain the ingredient Leptin. In fact, the stimulant free versions of weight loss supplements that contain leptin have shown significant weight loss results.
So now you are probably asking yourself "What is leptin?" Well, Leptin is a small peptide hormone that plays a role in deciding the quantity of food we consume. When leptin levels are excessive, appetite is reduced and energy expenditure is heightened. When taken in supplement form, Leptin can work to help increase fat burning and improve lean muscle mass.
Leptin is found in the gastric epithelium,placenta and adipose tissue. It is most abundant in white adipose tissue. Leptin binds to receptors in the hypothalamus region of the brain. When levels are low, the body is warned of limited energy supplies. If leptin levels are high, the hypothalamus senses the body as being overweight.
This excess leptin signals our bodies to eat less and expend more energy. This leads to weightloss. Burning more calories than you are consuming. The metabolic effects of leptin are such that leptin inhibits acetyl-CoA carboxylase,the enzyme required for synthesis of fatty acids and triglycerides. Leptin can also cause an boost in the fat burning. The inhibition of acetyl-CoA encourages the mobilization of fatty acids from storage sites and simultaneously discourages synthesis.
It is common knowledge that we slow down a little as we age and our leptin levels begin to dip. These lower leptin levels are associated with dieting and hitting a plateau. Supplementing with leptin can lower appetite,especially for carbohydrates, and increase energy expenditure.
